Human RTN4IP1 activation kit by CRISPRa

CAT#: GA113704

RTN4IP1 CRISPRa kit - CRISPR gene activation of human reticulon 4 interacting protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RTN4IP1
• Locus ID: 84816
• Kit Components:

  GA113704G1, RTN4IP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113704G2, RTN4IP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113704G3, RTN4IP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318746, NM_032730
• Synonyms: NIMP; OPA10
• Summary: This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]