Human TRIM5 alpha (TRIM5) activation kit by CRISPRa

CAT#: GA113859

TRIM5 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM5
• Locus ID: 85363
• Kit Components:

  GA113859G1, TRIM5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113859G2, TRIM5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113859G3, TRIM5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_033034, NM_033092, NM_033093
• Synonyms: RNF88; TRIM5alpha
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]