Human XRCC6BP1 (ATP23) activation kit by CRISPRa

CAT#: GA114113

ATP23 CRISPRa kit - CRISPR gene activation of human ATP23 metallopeptidase and ATP synthase assembly factor homolog

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP23
• Locus ID: 91419
• Kit Components:

  GA114113G1, ATP23 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114113G2, ATP23 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114113G3, ATP23 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320408, NM_001320409, NM_001320410, NM_033276
• Synonyms: KUB3; XRCC6BP1
• Summary: The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]