Human CABLES1 activation kit by CRISPRa

CAT#: GA114153

CABLES1 CRISPRa kit - CRISPR gene activation of human Cdk5 and Abl enzyme substrate 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CABLES1
• Locus ID: 91768
• Kit Components:

  GA114153G1, CABLES1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114153G2, CABLES1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114153G3, CABLES1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001100619, NM_001256438, NM_138375, NR_023359
• Synonyms: CABL1; CABLES; HsT2563; IK3-1
• Summary: This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]