Human G6PC3 activation kit by CRISPRa

CAT#: GA114223

G6PC3 CRISPRa kit - CRISPR gene activation of human glucose-6-phosphatase catalytic subunit 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: G6PC3
• Locus ID: 92579
• Kit Components:

  GA114223G1, G6PC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114223G2, G6PC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114223G3, G6PC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319945, NM_138387, NR_028581, NR_028582
• Synonyms: SCN4; UGRP
• Summary: This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]