Human TIMM50 activation kit by CRISPRa

CAT#: GA114227

TIMM50 CRISPRa kit - CRISPR gene activation of human translocase of inner mitochondrial membrane 50

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIMM50
• Locus ID: 92609
• Kit Components:

  GA114227G1, TIMM50 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114227G2, TIMM50 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114227G3, TIMM50 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001563, NM_001329559
• Synonyms: TIM50; TIM50L
• Summary: This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016]