Human FOXP2 activation kit by CRISPRa

CAT#: GA114311

FOXP2 CRISPRa kit - CRISPR gene activation of human forkhead box P2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FOXP2
• Locus ID: 93986
• Kit Components:

  GA114311G1, FOXP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114311G2, FOXP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114311G3, FOXP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172766, NM_001172767, NM_001172777, NM_014491, NM_148898, NM_148899, NM_148900, NR_033766, NR_033767
• Synonyms: CAGH44; SPCH1; TNRC10
• Summary: This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]