Human HCP1 (SLC46A1) activation kit by CRISPRa

CAT#: GA114397

SLC46A1 CRISPRa kit - CRISPR gene activation of human solute carrier family 46 member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC46A1
• Locus ID: 113235
• Kit Components:

  GA114397G1, SLC46A1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114397G2, SLC46A1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114397G3, SLC46A1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242366, NM_080669
• Synonyms: G21; HCP1; PCFT
• Summary: This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]