Human LY108 (SLAMF6) activation kit by CRISPRa

CAT#: GA114477

SLAMF6 CRISPRa kit - CRISPR gene activation of human SLAM family member 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLAMF6
• Locus ID: 114836
• Kit Components:

  GA114477G1, SLAMF6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114477G2, SLAMF6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114477G3, SLAMF6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184714, NM_001184715, NM_001184716, NM_052931
• Synonyms: CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000
• Summary: The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]