Human Claudin 23 (CLDN23) activation kit by CRISPRa

CAT#: GA115278

CLDN23 CRISPRa kit - CRISPR gene activation of human claudin 23

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLDN23
• Locus ID: 137075
• Kit Components:

  GA115278G1, CLDN23 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115278G2, CLDN23 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115278G3, CLDN23 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_194284
• Synonyms: CLDNL; hCG1646163
• Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]