Human TRIF (TICAM1) activation kit by CRISPRa

CAT#: GA115649

TICAM1 CRISPRa kit - CRISPR gene activation of human toll like receptor adaptor molecule 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TICAM1
• Locus ID: 148022
• Kit Components:

  GA115649G1, TICAM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115649G2, TICAM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115649G3, TICAM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014261, NM_182919
• Synonyms: MGC35334; PRVTIRB; TICAM-1; TIR domain-containing adaptor molecule 1; TIR domain containing adaptor inducing interferon-beta; toll-like receptor adaptor molecule 1; TRIF; TRIF, PRVTIRB, TICAM-1, MGC35334
• Summary: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]