Human TTL activation kit by CRISPRa

CAT#: GA115753

TTL CRISPRa kit - CRISPR gene activation of human tubulin tyrosine ligase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TTL
• Locus ID: 150465
• Kit Components:

  GA115753G1, TTL gRNA vector 1 in pCas-Guide-CRISPRa

  GA115753G2, TTL gRNA vector 2 in pCas-Guide-CRISPRa

  GA115753G3, TTL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_153712
• Synonyms: MGC46235
• Summary: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]). [supplied by OMIM, Mar 2008]