Human UPP2 activation kit by CRISPRa

CAT#: GA115797

UPP2 CRISPRa kit - CRISPR gene activation of human uridine phosphorylase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UPP2
• Locus ID: 151531
• Kit Components:

  GA115797G1, UPP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115797G2, UPP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115797G3, UPP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135098, NM_173355
• Synonyms: UDRPASE2; UP2; UPASE2
• Summary: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. [UniProtKB/Swiss-Prot Function]