Human Zinc transporter 8 (SLC30A8) activation kit by CRISPRa

CAT#: GA116181

SLC30A8 CRISPRa kit - CRISPR gene activation of human solute carrier family 30 member 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC30A8
• Locus ID: 169026
• Kit Components:

  GA116181G1, SLC30A8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116181G2, SLC30A8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116181G3, SLC30A8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172811, NM_001172813, NM_001172814, NM_001172815, NM_173851
• Synonyms: ZnT-8; ZNT8
• Summary: The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]