Human RDHE2 (SDR16C5) activation kit by CRISPRa

CAT#: GA116258

SDR16C5 CRISPRa kit - CRISPR gene activation of human short chain dehydrogenase/reductase family 16C member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDR16C5
• Locus ID: 195814
• Kit Components:

  GA116258G1, SDR16C5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116258G2, SDR16C5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116258G3, SDR16C5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318049, NM_001318050, NM_138969
• Synonyms: RDH#2; RDH-E2; RDHE2
• Summary: This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]