Human U2AF1L3 (U2AF1L4) activation kit by CRISPRa

CAT#: GA116316

U2AF1L4 CRISPRa kit - CRISPR gene activation of human U2 small nuclear RNA auxiliary factor 1 like 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: U2AF1L4
• Locus ID: 199746
• Kit Components:

  GA116316G1, U2AF1L4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116316G2, U2AF1L4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116316G3, U2AF1L4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040425, NM_144987, NR_110171, NR_110172, NR_110173, NR_163171, NR_163172, NR_163173, NM_001369824, NR_163169, NR_163170
• Synonyms: U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1RS3; U2af26
• Summary: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA. [UniProtKB/Swiss-Prot Function]