U2AF1L3 (U2AF1L4) Human Gene Knockout Kit (CRISPR)

CAT#: KN406335

U2AF1L4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: U2AF1L4
• Locus ID: 199746
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001040425, NM_144987, NR_110171, NR_110172, NR_110173, NR_163171, NR_163172, NR_163173, NM_001369824, NR_163169, NR_163170
• Synonyms: U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1RS3; U2af26
• Summary: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA. [UniProtKB/Swiss-Prot Function]