Human Munc 13 4 (UNC13D) activation kit by CRISPRa

CAT#: GA116390

UNC13D CRISPRa kit - CRISPR gene activation of human unc-13 homolog D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UNC13D
• Locus ID: 201294
• Kit Components:

  GA116390G1, UNC13D gRNA vector 1 in pCas-Guide-CRISPRa

  GA116390G2, UNC13D gRNA vector 2 in pCas-Guide-CRISPRa

  GA116390G3, UNC13D gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_199242
• Synonyms: FHL3; HLH3; HPLH3; Munc13-4
• Summary: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]