Human JMJD1C activation kit by CRISPRa

CAT#: GA116586

JMJD1C CRISPRa kit - CRISPR gene activation of human jumonji domain containing 1C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: JMJD1C
• Locus ID: 221037
• Kit Components:

  GA116586G1, JMJD1C gRNA vector 1 in pCas-Guide-CRISPRa

  GA116586G2, JMJD1C gRNA vector 2 in pCas-Guide-CRISPRa

  GA116586G3, JMJD1C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282948, NM_001318153, NM_001318154, NM_004241, NM_032776, NR_134512, NM_001322252, NM_001322254, NM_001322258
• Synonyms: TRIP8
• Summary: The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]