Human MCOLN2 activation kit by CRISPRa

CAT#: GA116814

MCOLN2 CRISPRa kit - CRISPR gene activation of human mucolipin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MCOLN2
• Locus ID: 255231
• Kit Components:

  GA116814G1, MCOLN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116814G2, MCOLN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116814G3, MCOLN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_153259, NM_001330647
• Synonyms: TRP-ML2; TRPML2
• Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]). [supplied by OMIM, Sep 2009]