Human Occludin (OCLN) activation kit by CRISPRa

CAT#: GA119306

OCLN CRISPRa kit - CRISPR gene activation of human occludin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OCLN
• Locus ID: 100506658
• Kit Components:

  GA119306G1, OCLN gRNA vector 1 in pCas-Guide-CRISPRa

  GA119306G2, OCLN gRNA vector 2 in pCas-Guide-CRISPRa

  GA119306G3, OCLN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001205254, NM_001205255, NM_002538
• Synonyms: BLCPMG; PPP1R115
• Summary: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]