Human MICA activation kit by CRISPRa

CAT#: GA119322

MICA CRISPRa kit - CRISPR gene activation of human MHC class I polypeptide-related sequence A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MICA
• Locus ID: 100507436
• Kit Components:

  GA119322G1, MICA gRNA vector 1 in pCas-Guide-CRISPRa

  GA119322G2, MICA gRNA vector 2 in pCas-Guide-CRISPRa

  GA119322G3, MICA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000247, NM_001177519, NM_001289152, NM_001289153, NM_001289154, NR_036523, NR_036524
• Synonyms: MIC-A; PERB11.1
• Summary: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]