Mouse Apoa2 activation kit by CRISPRa

CAT#: GA200237

Apoa2 CRISPRa kit - CRISPR gene activation of mouse apolipoprotein A-II

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Apoa2
• Locus ID: 11807
• Kit Components:

  GA200237G1, Apoa2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200237G2, Apoa2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200237G3, Apoa2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001305549, NM_001305550, NM_001305585, NM_013474, NR_131173
• Synonyms: Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII; Hdl-1
• Summary: This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]