Mouse Bmp8a activation kit by CRISPRa

CAT#: GA200423

Bmp8a CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein 8a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bmp8a
• Locus ID: 12163
• Kit Components:

  GA200423G1, Bmp8a gRNA vector 1 in pCas-Guide-CRISPRa

  GA200423G2, Bmp8a gRNA vector 2 in pCas-Guide-CRISPRa

  GA200423G3, Bmp8a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256019, NM_007558
• Synonyms: Bmp7r1; OP-2; OP2
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]