Mouse Csf1 activation kit by CRISPRa

CAT#: GA200912

Csf1 CRISPRa kit - CRISPR gene activation of mouse colony stimulating factor 1 (macrophage)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Csf1
• Locus ID: 12977
• Kit Components:

  GA200912G1, Csf1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200912G2, Csf1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200912G3, Csf1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001113529, NM_001113530, NM_007778
• Synonyms: C87615; Csfm; MCSF; op
• Summary: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. [UniProtKB/Swiss-Prot Function]