Mouse Cyp24a1 activation kit by CRISPRa

CAT#: GA200974

Cyp24a1 CRISPRa kit - CRISPR gene activation of mouse cytochrome P450, family 24, subfamily a, polypeptide 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cyp24a1
• Locus ID: 13081
• Kit Components:

  GA200974G1, Cyp24a1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200974G2, Cyp24a1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200974G3, Cyp24a1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009996
• Synonyms: 24-OHase; CP24; Cyp24
• Summary: The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]