Mouse Gabrg2 activation kit by CRISPRa

CAT#: GA201523

Gabrg2 CRISPRa kit - CRISPR gene activation of mouse gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gabrg2
• Locus ID: 14406
• Kit Components:

  GA201523G1, Gabrg2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201523G2, Gabrg2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201523G3, Gabrg2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008073, NM_177408, NM_001362655, NM_001362656
• Synonyms: GABAA-R; Gabrg-2; gamma2
• Summary: This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]