Mouse Il13ra2 activation kit by CRISPRa

CAT#: GA202124

Il13ra2 CRISPRa kit - CRISPR gene activation of mouse interleukin 13 receptor, alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il13ra2
• Locus ID: 16165
• Kit Components:

  GA202124G1, Il13ra2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202124G2, Il13ra2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202124G3, Il13ra2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001306059, NM_008356
• Synonyms: CD213a2; IL-13R-alpha-2
• Summary: This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]