Mouse Il15 activation kit by CRISPRa

CAT#: GA202125

Il15 CRISPRa kit - CRISPR gene activation of mouse interleukin 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il15
• Locus ID: 16168
• Kit Components:

  GA202125G1, Il15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202125G2, Il15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202125G3, Il15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001254747, NM_008357
• Synonyms: AI503618; IL-15
• Summary: This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]