Mouse Mmp2 activation kit by CRISPRa

CAT#: GA202681

Mmp2 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp2
• Locus ID: 17390
• Kit Components:

  GA202681G1, Mmp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202681G2, Mmp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202681G3, Mmp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008610
• Synonyms: Clg4a; GelA; MMP-2
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]