Mouse Muc1 activation kit by CRISPRa

CAT#: GA202759

Muc1 CRISPRa kit - CRISPR gene activation of mouse mucin 1, transmembrane

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Muc1
• Locus ID: 17829
• Kit Components:

  GA202759G1, Muc1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202759G2, Muc1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202759G3, Muc1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013605
• Synonyms: CD227; EMA; Muc-1
• Summary: The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, Src and NF-kappaB pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity. [UniProtKB/Swiss-Prot Function]