Mouse Pnoc activation kit by CRISPRa

CAT#: GA202949

Pnoc CRISPRa kit - CRISPR gene activation of mouse prepronociceptin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pnoc
• Locus ID: 18155
• Kit Components:

  GA202949G1, Pnoc gRNA vector 1 in pCas-Guide-CRISPRa

  GA202949G2, Pnoc gRNA vector 2 in pCas-Guide-CRISPRa

  GA202949G3, Pnoc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001205075, NM_010932
• Synonyms: N/OFQ; Npnc1; OFQ/N
• Summary: This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]