Mouse Pdyn activation kit by CRISPRa

CAT#: GA203167

Pdyn CRISPRa kit - CRISPR gene activation of mouse prodynorphin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pdyn
• Locus ID: 18610
• Kit Components:

  GA203167G1, Pdyn gRNA vector 1 in pCas-Guide-CRISPRa

  GA203167G2, Pdyn gRNA vector 2 in pCas-Guide-CRISPRa

  GA203167G3, Pdyn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286502, NM_018863
• Synonyms: Dyn
• Summary: This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to function as the body's natural way to control addiction. These peptides have been associated with depression, stress, anxiety, response to pain, and maintenance of homeostasis via circadian rhythms and control of appetite. Mutations in the related human gene have been linked to the neurodegenerative disease spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]