Mouse Tcea2 activation kit by CRISPRa

CAT#: GA204230

Tcea2 CRISPRa kit - CRISPR gene activation of mouse transcription elongation factor A (SII), 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Tcea2
• Locus ID: 21400
• Kit Components:

  GA204230G1, Tcea2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204230G2, Tcea2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204230G3, Tcea2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009326, NM_001356342, NM_001356343
• Synonyms: AI326274; S-II-T1; SII-T1; Tceat
• Summary: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. [UniProtKB/Swiss-Prot Function]