Mouse Trpc6 activation kit by CRISPRa

CAT#: GA204457

Trpc6 CRISPRa kit - CRISPR gene activation of mouse transient receptor potential cation channel, subfamily C, member 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Trpc6
• Locus ID: 22068
• Kit Components:

  GA204457G1, Trpc6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204457G2, Trpc6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204457G3, Trpc6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282086, NM_001282087, NM_013838
• Synonyms: AV025995; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; TRP-6; Trrp6
• Summary: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. [UniProtKB/Swiss-Prot Function]