Mouse Vldlr activation kit by CRISPRa

CAT#: GA204604

Vldlr CRISPRa kit - CRISPR gene activation of mouse very low density lipoprotein receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Vldlr
• Locus ID: 22359
• Kit Components:

  GA204604G1, Vldlr gRNA vector 1 in pCas-Guide-CRISPRa

  GA204604G2, Vldlr gRNA vector 2 in pCas-Guide-CRISPRa

  GA204604G3, Vldlr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161420, NM_001347441, NM_013703
• Synonyms: AA408956; AI451093; AW047288
• Summary: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. [UniProtKB/Swiss-Prot Function]