Mouse Ikzf1 activation kit by CRISPRa

CAT#: GA204742

Ikzf1 CRISPRa kit - CRISPR gene activation of mouse IKAROS family zinc finger 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ikzf1
• Locus ID: 22778
• Kit Components:

  GA204742G1, Ikzf1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204742G2, Ikzf1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204742G3, Ikzf1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001025597, NM_001301863, NM_001301865, NM_001301866, NM_001301868, NM_009578
• Synonyms: 5832432G11Rik; hlk-1; Ikaros; LyF-1; mKIAA4227; Zfpn1a1; Znfn1a1
• Summary: The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]