Mouse Bace1 activation kit by CRISPRa

CAT#: GA204766

Bace1 CRISPRa kit - CRISPR gene activation of mouse beta-site APP cleaving enzyme 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bace1
• Locus ID: 23821
• Kit Components:

  GA204766G1, Bace1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204766G2, Bace1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204766G3, Bace1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145947, NM_011792
• Synonyms: ASP2; Bace; C76936
• Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]