Mouse Nr0b2 activation kit by CRISPRa

CAT#: GA204831

Nr0b2 CRISPRa kit - CRISPR gene activation of mouse nuclear receptor subfamily 0, group B, member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nr0b2
• Locus ID: 23957
• Kit Components:

  GA204831G1, Nr0b2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204831G2, Nr0b2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204831G3, Nr0b2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_011850
• Synonyms: SHP; SHP-1; Shp1
• Summary: This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded orphan receptor lacks a DNA binding domain but modulates gene expression by interacting with other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]