Mouse Gemin2 activation kit by CRISPRa

CAT#: GA206863

Gemin2 CRISPRa kit - CRISPR gene activation of mouse gem nuclear organelle associated protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gemin2
• Locus ID: 66603
• Kit Components:

  GA206863G1, Gemin2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206863G2, Gemin2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206863G3, Gemin2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025656
• Synonyms: gemin-2; Sip1
• Summary: This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. [provided by RefSeq, Sep 2015]