Mouse Yaf2 activation kit by CRISPRa

CAT#: GA207113

Yaf2 CRISPRa kit - CRISPR gene activation of mouse YY1 associated factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Yaf2
• Locus ID: 67057
• Kit Components:

  GA207113G1, Yaf2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA207113G2, Yaf2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA207113G3, Yaf2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024189, NR_028315
• Synonyms: 2810021M11Rik
• Summary: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. [UniProtKB/Swiss-Prot Function]