Mouse Fgb activation kit by CRISPRa

CAT#: GA212287

Fgb CRISPRa kit - CRISPR gene activation of mouse fibrinogen beta chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fgb
• Locus ID: 110135
• Kit Components:

  GA212287G1, Fgb gRNA vector 1 in pCas-Guide-CRISPRa

  GA212287G2, Fgb gRNA vector 2 in pCas-Guide-CRISPRa

  GA212287G3, Fgb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_181849
• Synonyms: 2510049G14Rik
• Summary: This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]