Mouse Mars activation kit by CRISPRa

CAT#: GA213352

Mars CRISPRa kit - CRISPR gene activation of mouse methionine-tRNA synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mars
• Locus ID: 216443
• Kit Components:

  GA213352G1, Mars gRNA vector 1 in pCas-Guide-CRISPRa

  GA213352G2, Mars gRNA vector 2 in pCas-Guide-CRISPRa

  GA213352G3, Mars gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003913, NM_001171582
• Synonyms: Metrs; Mtrns
• Summary: The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]