Mouse Col27a1 activation kit by CRISPRa

CAT#: GA216993

Col27a1 CRISPRa kit - CRISPR gene activation of mouse collagen, type XXVII, alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Col27a1
• Locus ID: 373864
• Kit Components:

  GA216993G1, Col27a1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA216993G2, Col27a1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA216993G3, Col27a1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025685
• Synonyms: 5730512J02Rik; AI449266
• Summary: This gene encodes the alpha-1 subunit of type XXVII collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein forms a homotrimeric triple helical procollagen that undergoes proteolytic processing during fibril formation. Transgenic mice lacking a portion of the collagenous domain in the encoded protein exhibit skeletal abnormalities, chondrodysplasia and die at birth because of a lung defect. [provided by RefSeq, Dec 2015]