Calcipressin 1 (RCAN1) Human Gene Knockout Kit (CRISPR)

CAT#: KN202391RB

RCAN1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Calcipressin 1
• Locus ID: 1827
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001285389, NM_001285391, NM_001285392, NM_001285393, NM_001331016, NM_004414, NM_203417, NM_203418
• Synonyms: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
• Summary: 'The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]'