Human Calcipressin 1 (RCAN1) activation kit by CRISPRa

CAT#: GA101278

RCAN1 CRISPRa kit - CRISPR gene activation of human regulator of calcineurin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RCAN1
• Locus ID: 1827
• Kit Components:

  GA101278G1, Calcipressin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101278G2, Calcipressin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101278G3, Calcipressin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001285389, NM_001285391, NM_001285392, NM_001285393, NM_001331016, NM_004414, NM_203417, NM_203418
• Synonyms: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
• Summary: 'The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]'