PDLIM5 Human Gene Knockout Kit (CRISPR)

CAT#: KN400592

PDLIM5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: PDLIM5
• Locus ID: 10611
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001011513, NM_001011514, NM_001011515, NM_001011516, NM_001256425, NM_001256426, NM_001256427, NM_001256428, NM_001256429, NM_006457, NR_003257, NR_024179, NR_046186
• Synonyms: ENH; ENH1; L9; LIM
• Summary: This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]