LYRM1 Human Gene Knockout Kit (CRISPR)

CAT#: KN402041

LYRM1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: LYRM1
• Locus ID: 57149
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001128301, NM_001128302, NM_001302835, NM_001302836, NM_020424, NR_126516, NR_126520, NR_126521, NR_126527, NR_126528, NM_001369632, NM_001369633, NM_001369635, NM_001369636, NM_001369638, NM_001369639, NM_001369641, NM_001369642, NM_001369644, NR_161425, NR_161426, NR_161429, NR_161430, NM_001369631, NM_001369634, NM_001369637, NM_001369645, NR_161427, NR_161431, NR_161432
• Synonyms: A211C6.1
• Summary: The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]