PDE4D Human Gene Knockout Kit (CRISPR)

CAT#: KN412410

PDE4D - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: PDE4D
• Locus ID: 5144
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001104631, NM_001165899, NM_001197218, NM_001197219, NM_001197220, NM_001197221, NM_001197222, NM_001197223, NM_006203, NM_001349241, NM_001349242, NM_001349243, NM_001364599, NM_001364600, NM_001364602, NM_001364601, NM_001364603, NM_001364604
• Synonyms: ACRDYS2; DPDE3; HSPDE4D; PDE4DN2; PDE43; STRK1
• Summary: 'This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]'