CEP250 Human Gene Knockout Kit (CRISPR)

CAT#: KN413542

CEP250 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: CEP250
• Locus ID: 11190
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001035518, NM_001318219, NM_007186
• Synonyms: C-NAP1; centrosomal Nek2-associated protein 1; centrosomal protein, 250-KD; centrosomal protein 2; centrosomal protein 250kDa; centrosome associated protein; CEP2; CNAP1; MGC88542; OTTHUMP00000030757
• Summary: This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]